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Lifecourse Biology

From development to disease and the clinic

Welcome

The Bateson Centre at the University of Sheffield is a national centre for lifecourse biology – a multidisciplinary field at the interface of developmental biology, cell biology, stem cell biology, imaging, mathematical modelling and translational biomedicine.

This conference will bring together leading researchers from international, UK and Sheffield-based institutes.

By gathering experts in these key areas of lifecourse research and giving them an arena in which to interact we seek to develop cross-cutting understanding of one another’s fields of research.

About the Meeting

As life expectancy increases and populations age, we – as a society – are being increasingly confronted with diseases of old age. As such, a holistic understanding how the body changes over the course of its entire life has the potential to provide insights of great significance.

Lifecourse Biology seeks to understand the arc of human existence: from the fertilized egg, through healthy childhood and adulthood and into ageing and degeneration. It encompasses the changes that occur throughout life, particularly the processes of morphogenesis, tissue remodeling, degeneration and repair. The Bateson Centre at the University of Sheffield is a national centre for lifecourse biology – a multidisciplinary field, built on whole organism physiology and in vivo imaging at the interface of developmental biology, cell biology, stem cell biology, imaging, mathematical modelling and translational biomedicine.

This conference seeks to bring together leading researchers in key areas of lifecourse research and give them an arena in which to interact and develop crosscutting understanding of one another’s fields of research. As a consequence, this meeting aims to be more than the sum of its [outstanding] parts, also seeking to promote and foster innovative interdisciplinary systems approaches. For example, strong synergy links the knowledge, skills and approaches used in developmental biology to the processes that maintain and promote tissue stem cells, organ regeneration and homeostasis in the adult.

Ultimately, it is only by developing such holistic, collaborative approaches that we can properly define and address the big challenges of the 21st century.

Realizing these challenges, the Bateson Centre at the University of Sheffield was established in 2014 and named after the early 20th century geneticist William Bateson. It seeks to bring together basic researchers and clinicians with a common thread of using animal models to address questions surrounding lifecourse biology. It is anticipated that this conference will be the key meeting of the year for many Bateson Centre members.

Speakers

Markus Affolter

Biozentrum der Uni Basel

Philip Ingham

Lee Kong Chian School of Medicine, Singapore and Living Systems Institute, Exeter

Roger Patient

Weatherall Institute of Molecular Medicine, Oxford

Caroline Savage

GlaxoSmithKline

Christine Watson

University of Cambridge

Steve Farber

Carnegie Institution for Science, Baltimore

Gil Levkowitz

The Weizmann Institute of Science, Israel

Eugenia Piddini

University of Bristol

Owen Tamplin

University of Illinois at Chicago

Steve Wilson

UCL, London

Yi Feng

University of Edinburgh

Calum MacRae

Brigham and Womens’ Hospital, Boston

Liz Robertson

Sir William Dunn School of Pathology, Oxford

Jean-Paul Vincent

The Francis Crick Institute, London

We are a group of scientist and clinician researchers with the shared goal of understanding life, development and disease using genetics and visualisation.

Timetable

Wednesday 13th September

12.00pm-4.00pm
Arrival and Registration

4.00pm
Welcome and opening remarks – Professor Stephen Renshaw

4.30pm
Keynote Lecture I – Professor Calum MacRae (Boston) – title to follow

5.20pm
Dr Iwan Evans (Sheffield) – Uncleared Apoptotic Cells Dampen Macrophage Inflammatory Responses in Drosophila Embryos

5.40pm
Dr Nasreen Akhtar (Sheffield) – Mammary tissue shaping by the β1-integrin mechanoreceptor

6.00-9.00pm
Mixer/Reception
Open poster viewing

Thursday 14th September

8.30am
Arrival coffee

9.00am-10.30am
From Development to Disease Session 1: Systems Development and Function

9.00am
Professor Markus Affolter (Basel) – Angiogenesis in the zebrafish embryo: novel mechanisms and novel tools

9.35am
Professor Gil Levkowitz (Israel) – How a key interface between the brain’s neuro-hormonal and vascular systems is assembled

10.10am
Dr Alex Fletcher (Sheffield) – Mechanocellular modelling of epithelial morphogenesis

10.30am-11.00am
Coffee

11.00am
Dr Matt Towers (Sheffield) – Vertebrate limb development: Insights from the chick

11.20am
Dr Joe Rainger (Roslin) – Investigating the causes of optic fissure closure defects – a complimentary approach in humans and chick

11.40am
Professor Steve Farber (Baltimore) – Fishing for regulators: Live imaging of Intestinal lipid flux through lipoproteins and lipid droplets using the larval zebrafish

12.15pm-2.30pm
Lunch – Open poster viewing – Commercial exhibits

2.30pm-6.35pm
From Development to Disease Session 2 – Tissue Homeostasis

2.30pm
Professor Liz Robertson (Oxford) – Maturation of the developing gut is regulated by the zinc finger transcription factor Blimp1/Prdm1

3.05pm
Dr JP Vincent (Francis Crisk) – Precision Wnt signalling

3.40pm
Dr Prisca Chapouton (Munich) – The proteome of adult neural stem cells in zebrafish reveals age-related changes in responsiveness to IGF

4.00pm-4.30pm
Tea

4.30pm
Professor Christine Watson (Cambridge) – The developmental cycle of the mammary gland

5.05pm
Dr Adam Dobson (UCL) – Programming of Drosophila lifespan by diet, insulin signalling and FOXO

5.25pm
Dr Catarina Henriques (Sheffield) – A new role for telomerase in regulating gut immunity? Potential implications for ageing and disease

5.45pm
Keynote Lecture II – Professor Steve Wilson (UCL) – The developing brain: from genes to circuits and behaviour in health and disease

7.00pm-9.00pm
Dinner

Friday 15th September

8.30am
Arrival coffee

9.00am-10.30am
From Disease to the Clinic Session 1 – Repair and Remodelling

9.00am
Professor Roger Patient (Oxford) – Generation and regeneration of blood and the cardiovascular system

9.35am
Professor Owen Tamplin (Chicago) – Modeling the Hematopoietic Stem Cell Niche in Zebrafish

10.10am
Dr Anestis Tsakiridis (Sheffield) – In vitro generation of posterior neural cell types using human pluripotent stem cells

10.30am-11.00am
Coffee

11.00am-4.00pm
From Disease to the Clinic Session 2 – Translating Developmental Biology

11.00am
Dr Eugenia Piddini (Bristol) – Cell competition: lessons for cancer and regenerative medicine

11.35am
Dr Yi Feng (Edinburgh) – in vivo live imaging tumour initiation in a zebrafish model

12.10pm
Professor Philip Ingham (Exeter) – Hedgehog Signalling: from flies, to fish to therapy

12.45pm
Dr Kyra Campbell (Sheffield) – Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth

13.05pm-2.05pm
Lunch

2.05pm
Round Table Discussion: Lifecourse Biology: Opportunities and Barriers

Professor Andrew Copp (UCL) – From a mouse model to a possible new preventive therapy for neural tube defects

Dr Martin Zeidler (Sheffield) – JAK/STAT inhibitors in human disease: repurposing methotrexate

3.00pm
Keynote Lecture III – Professor Caroline Savage (GSK) – Picking the winners: New targets and their translation to the clinic

3.50pm
Closing remarks

4.00pm
Close

Register

Student/international attendee Bursary application

Deadline: 21st August 2017

Click here to apply for a Bursary

Registration Deadline

Extended to 21st August 2017

Click here to book your place 

The symposium package includes full access to all 3 days of the meeting, including talks, commercial exhibits and poster sessions. As well as an evening buffet reception on day 1, mid morning and mid afternoon tea and coffee and lunch on days 2 and 3. 

Onsite accommodation for 13th and 14th September and a place at the Symposium dinner can also be booked online.

Lifecourse Symposium Posters

Download our posters

Poster 1 | Poster 2

Location

The meeting will take place at The Edge, a purpose built conference and accommodation complex.

The Edge
34 Endcliffe Crescent
Endcliffe
Sheffield
South Yorkshire
S10 3ED

Sponsors

Contact Us

If you would like further information about our lifecourse symposium or The Bateson Centre then please get in touch.

+44 (0)114 222 2710

The Bateson Centre
Firth Court
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom

Contact

If you would like further information about our lifecourse symposium or The Bateson Centre then please get in touch.

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